Enteric-coated mycophenolate sodium: role in transplantation
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چکیده
منابع مشابه
Pharmacokinetics of mycophenolate sodium and comparison with the mofetil formulation in stable kidney transplant recipients.
BACKGROUND AND OBJECTIVES The introduction of mycophenolate mofetil has improved graft survival after organ transplantation; however, its use may be limited by important adverse effects. For overcoming these problems, an enteric-coated formulation of mycophenolate sodium has been developed, but pharmacokinetic data of mycophenolic acid release from this formulation are scanty. DESIGN, SETTING...
متن کاملEnteric-coated mycophenolate sodium is therapeutically equivalent to mycophenolate mofetil in de novo renal transplant patients.
The introduction of mycophenolate mofetil (MMF) represented a major advance in transplant medicine, although optimal use may be limited by gastrointestinal (GI) side-effects. An enteric-coated formulation of mycophenolate sodium (EC-MPS; myfortic) has been developed with the aim of improving the upper GI tolerability of mycophenolic acid. Therapeutic equivalence of EC-MPS (720 mg b.i.d.) and MM...
متن کاملPharmacokinetics and Pharmacodynamics of Mycophenolate in Patients After Renal Transplantation
Mycophenolic-acid (MPA) is a selective, non-competitive inhibitor of InosineMonophosphate-Dyhydrogenase (IMPDH) leading to the inhibition of the de-novo synthesis of guanosine-nucleotides. In human lymphocytes inhibition of IMPDH results in altered cellular proliferation with arrest in the S-phase of the cell cycle. Due to the absence of a salvage pathway, proliferating activated t-cells are se...
متن کاملComparing outcomes associated with dose manipulations of enteric-coated mycophenolate sodium versus mycophenolate mofetil in renal transplant recipients.
BACKGROUND This study assessed the incidence of reported gastrointestinal (GI) complications in patients treated with enteric-coated mycophenolate sodium (EC-MPS) versus mycophenolate mofetil (MMF) and to examine the impact of dose manipulations on biopsy-proven acute rejection (BPAR). METHODS A retrospective study was conducted in 379 renal transplant recipients initiated on EC-MPS or MMF th...
متن کاملDiagnosis by inclusion
Diarrhoea after renal transplantation is not an uncommon problem [1]. We present the case of a 61-year-old renal transplant recipient on mycophenolate mofetil (MMF) and steroids who presented with chronic diarrhoea and substantial weight loss. The diarrhoea was ascribed to MMF and the patient was converted to enteric-coated mycophenolic sodium (EC-MPS), without effect. Comprehensive workup reve...
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